兰州大学

姓名：王少华   ( 男 ) 
职称职务：副教授
电子邮箱：wangshh@lzu.edu.cn

学习与工作经历

1997年9月-2001年6月    兰州大学，化学化工学院化学专业，获学士学位；
2001年9月-2006年6月    兰州大学，化学化工学院有机化学专业，博士学位，导师：涂永强院士
2006年7月-2011年8月    MayoClinic，Department of Molecular Pharmacology & Experimental Therapeutics，高级研究助理
2011年8月-今           兰州大学，药学院，副教授

教学工作与成果

负责本科生《分析化学》和 研究生 《专业外语》的教学工作。

科研项目与成果

1.    Yong-Qiang Zhang, Dao-Yong Zhu, Bao-Sheng Li, Yong-Qiang Tu,* Ji-Xing Liu, Yong Lu，Shao-Hua Wang* 
Palladium-Catalyzed Cascade Process to Construct 2, 5-Disubstituted Pyrroles
Submitted
2.    Yuan-Ping Pang,* J. G. Park, Shao-Hua Wang, A. Vummenthala, R. K. Mishra, J. E. McLaughlin, R. Di, J. N. Kahn, N. E. Tumer, L. Janosi, J. Davis, C. B. Millard. 
Small Molecule Inhibitor Leads of Ribosome-Inactivating Proteins Developed Using the Door-stop  Approach.
PLoS ONE, 2011, 6, e17883.
3.    Yuan-Ping Pang,* J. Davis,* Shao-Hua Wang, J. G. Park, M. P. Nambiar, James J. Schmidt, C. B. Millard. 
Small Molecules Showing Significant Protection of Mice against Botulinum Neurotoxin Serotype A.
PLoS ONE, 2010, 5, e10129.
4.    Yuan-Ping Pang,* A. Vummenthala, R. K. Mishra, J. G. Park, Shao-Hua Wang, J. Davis, C. B. Millard, James J. Schmidt. 
Potent New Small-Molecule Inhibitor of Botulinum Neurotoxin Serotype A Endopeptidase Developed by Synthesis-Based Computer-Aided Molecular Design.
PLoS ONE, 2009, 4, e7730.
5.    Jian-Dong Liu, Shao-Hua Wang, Fu-Min Zhang, Yong-Qiang Tu,* Yong-Qiang Zhang. 
Concise Total Synthesis of (±)-Crinine.
Synlett, 2009, 12, 3040-3042.
6.    Fu-Min Zhang, Yong-Qiang Tu,* Jian-Dong Liu, Xiao-Hui Fan, Lei Shi, Xiang-Dong Hu, Shao-Hua Wang, Yong-Qiang Zhang. 
A general approach to crinine-type Amaryllidaceae alkaloids: total syntheses of (±)-haemanthidine, (±)-pretazettine, (±)-tazettine, and (±)-crinamine.
Tetrahedron, 2006, 62, 9446-9455.
7.    Shao-Hua Wang, Yong-Qiang Tu,* Min Wang. 
t-BuOK promoted coupling of alkynes and aldehydes: a concise synthetic method of beta,gamma-unsaturated enones.
Tetrahedron Lett., 2006, 47, 8621-8623.
8.    Shao-Hua Wang, Yong-Qiang Tu,* Pen Chen, Xiang-Dong Hu, Fu-Min Zhang, Ai-Xia Wang. 
KOtBu-promoted three-component coupling of aldehydes and alkynes: Highly efficient synthesis of 1-En-4-yn-3-ols and 2-En-4-yn-1-ols.
J. Org. Chem., 2006, 71, 4343-4345.
9.    Shao-Hua Wang, Yong-Qiang Tu,* Pen Chen. 
Enantioselective addition of phenylacetylene to ketones catalyzed by titanium(IV) complexes of N-sulfonylated beta-amino alcohols.
Chinese J. Chem., 2006, 24, 165-168.
10.    Ai-Xia Wang, Yong-Qiang Tu,* Zhen-Lei Song, Dao-Yi Yuan, Xiang-Dong Hu, Shao-Hua Wang, Shuan-Hu Gao. 
Synthetically useful Wagner-Meerwein rearrangement of alpha-quaternary beta-bromovinyl methyl ethers.
Eur. J. Org. Chem., 2006, 12, 2691-2694.
11.    Xiang-Dong Hu, Yong-Qiang Tu,* En Zhang, Shuan-Hu Gao, Shao-Hua Wang, Ai-Xia Wang, Chun-An Fan, Min Wang. 
Total synthesis of (±)-galanthamine.
Org. Lett., 2006, 8, 1823-1825.
12.    Shuan-Hu Gao, Yong-Qiang Tu,* Xiang-Dong Hu, Shao-Hua Wang, Rong-Bao Hua, Yi-Jun Jiang, Yu-Ming Zhao, Xiao-Hui Fan, Shu-Yu Zhang. 
General and efficient strategy for erythrinan and homoerythrinan alkaloids: Syntheses of (±)-3-demethoxyerythratidinone and (±)-erysotramidine.
Org. Lett., 2006, 8, 2373-2376.
13.    Shao-Hua Wang, Fei Wang, Fu-Min Zhang, Chun-An Fan, Yong-Qiang Tu,* Shi-Kuo Ren. 
Kinetic resolution of beta-hydroxy epoxides promoted by chiral aluminium reagents.
Chinese J. Org. Chem., 2005, 25, 1302-1305.
14.    Min Wang, Bao-Min Wang, Lei Shi, Yong-Qiang Tu,* Chun-An Fan, Shao-Hua Wang, Xiang-Dong Hu, Shu-Yu Zhang. 
Quinine/selectfluor combination induced asymmetric semipinacol rearrangement of allylic alcohols: an effective and enantioselective approach to alpha-quaternary beta-fluoro aldehydes.
Chem. Commun., 2005, 5580-5582.
15.    Pei-Nian Liu, Jin-Gen Deng, Yong-Qiang Tu,* Shao-Hua Wang. 
Highly efficient and recyclable heterogeneous asymmetric transfer hydrogenation of ketones in water.
Chem. Commun., 2004,  2070-2071.
16.    Xue-Qiang Li, Hong Wang, Yong-Qiang Tu,* Shao-Hua Wang. 
Synthetic studies of the HIV-  inhibitive marine natural products synthesis of the C1 similar to C7 fragment of didemnaketal A.
Acta Chim. Sinica, 2004, 62, 839-841, (2004)
17.    Fei Wang, Shao-Hua Wang, Yong-Qiang Tu,* Shi-Kuo Ren. 
AlEt3-promoted eliminative ring-opening of beta-hydroxy epoxides: highly stereoselective synthesis of terminal alpha-hydroxy olefins.
Tetrahedron-Asymmetry, 2003, 14, 2189-2193.
18.    Fei Wang, Yong-Qiang Tu,* Chun-An Fan, Shao-Hua Wang, Fu-Min Zhang. 
Kinetic resolution via semipinacol rearrangement of alpha-hydroxy epoxides: a new method for asymmetric synthesis of alpha-hydroxy epoxides and beta-hydroxy ketones containing an alpha-quaternary carbon.
Tetrahedron-Asymmetry, 2002, 13, 395-298.

研究与招生方向

有机合成方法学和天然产物全合成
具有生物（药物）活性的小分子的设计与合成
高通量小分子活性测定方法的设计