西南大学

西南大学化学化工学院硕士研究生导师向云信息介绍：

向云 （Yun Xiang）, 博士

教授，博士生导师

邮件地址：yunatswu@swu.edu.cn

通讯地址：重庆市北碚区西南大学化学化工学院 400715

教育经历：

2005. 1~2008. 10 美国亚利桑那州立大学 分析化学 博士学位

2003. 8~2004. 12 美国新墨西哥州立大学 分析化学 博士研究生

2000. 9~2003. 7  四川大学化学学院 工业催化 硕士学位

1995. 9~1999. 7  四川大学化学学院 仪器分析 学士学位

工作经历：

2011. 7~至今 西南大学化学化工学院 教授

2008. 12~2011. 6 西南大学化学化工学院 特聘教授

2005. 1~2008. 10 美国亚利桑那州立大学 Research Assistant

2003. 8~2004. 12 美国新墨西哥州立大学 Teaching Assistant

研究方向：

生物传感器（Biosensors）、生物电分析化学（Bio-electroanalysis）、纳米生物技术（Nanobiotechnology）

研究内容：

1.基于新型纳米材料分析信号放大的疾病标志物高灵敏电化学生物传感

2.生物分子的可视化分析

3.DNA自组装及DNA纳米结构在生物分析中的应用

主持课题：

1.国家自然科学基金青年－面上连续资助项目（2013–2016）

2.教育部新世纪优秀人才支持计划资助项目（2013–2015）

3.国家自然科学基金青年科学基金项目（2010）

4.留学回国人员科技活动资助项目（2012-2014）

5.中国博士后科学基金特别资助项目（2010-2012）

6.重庆市自然科学基金一般项目（2009-2012）

7.中央高校基本科研业务费专项资金重点项目（2009-2011）、团队项目（2012-2014）

8.西南大学博士基金（含引进人才计划）项目（2009）

代表论文：

1.Wenjiao Zhou,Xue Gong, Yun Xiang,* RuoYuan, YaqinChai, Target-triggered quadratic amplification for label-free and sensitive visual detection of cytokines based on hairpin aptamer DNAzyme probes, Analytical Chemistry, 2014, 86, 953–958.

2.Ying Chen, Mengli Yang, Yun Xiang,* Ruo Yuan,* Yaqin Chai, Binding-induced autonomous disassembly of aptamer-DNAzyme supersandwich nanostructures for sensitive electrochemiluminescence turn-on detection of Ochratoxin A, Nanoscale, 2014, 6, 1099–1104.

3.Qiong Wang,Cuiyun Yang, Yun Xiang,* RuoYuan, Yaqin Chai, Dual amplified and ultrasensitive electrochemical detection of mutant DNA biomarkers based on nuclease-assisted target recycling and rolling circle amplifications, Biosensors & Bioelectronics, 2014, 55, 266–271.

4.Wenjiao Zhou,Xue Gong, Yun Xiang,* RuoYuan, Yaqin Chai, Quadratic recycling amplification for label-free and sensitive visual detection of HIV DNA, Biosensors & Bioelectronics, 2014, 55, 220–224.

5.Jin Xu, Qiong Wang, Yun Xiang,* Ruo Yuan, Yaqin Chai, Cascade signal amplification for ultrasensitive electrochemical DNA detection, Analyst, 2014, 139, 128–132.

6.Wenjiao Zhou, Jiao Su, Yaqin Chai, Ruo Yuan, Yun Xiang,* Naked eye detection of trace cancer biomarkers based on biobarcode and enzyme-assisted DNA recycling hybrid amplifications, Biosensors & Bioelectronics, 2014, 53, 494–498.

7.Yunying Xu, Jin Xu, Yun Xiang,* Ruo Yuan, Yaqin Chai, Target-induced structure switching of hairpin aptamers for label-free and sensitive fluorescent detection of ATP via exonuclease-catalyzed target recycling amplification, Biosensors & Bioelectronics, 2014, 51, 293–296.

8.Jiao Su, Wenjiao Zhou, Yun Xiang,* Ruo Yuan, Yaqin Chai, Target-induced charge reduction of aptamers for visual detection of lysozyme based on positively charged gold nanoparticles, Chemical Communications, 2013, 49, 7659–7661.

9.Mengli Yang, Ying Chen, Yun Xiang,* Ruo Yuan, Yaqin Chai, In situ energy transfer quenching of quantum dot electrochemiluminescence for sensitive detection of cancer biomarkers, Biosensors & Bioelectronics, 2013, 50, 393–398.

10.Ying Chen, Mengli Yang, Yun Xiang,* Ruo Yuan,* Yaqin Chai, Ligase chain reaction amplification for sensitive electrochemiluminescent detection of single nucleotide polymorphisms, Analytica Chimica Acta, 2013, 796, 1–6.

11.Qiong Wang, Bingying Jiang, Jiaqing Xie, Yun Xiang,* Ruo Yuan, Yaqin Chai, Coupling of background reduction with rolling circle amplification for highly sensitive protein detection via terminal protection of small molecule-linked DNA, Analyst, 2013, 138, 5751–5756.

12.Ying Chen, Qiong Wang, Jin Xu, Yun Xiang,* Ruo Yuan,* Yaqin Chai, A new hybrid signal amplification strategy for ultrasensitive electrochemical detection of DNA based on enzyme-assisted target recycling and DNA supersandwich assemblies, Chemical Communications, 2013, 49, 2052–2054.

13.Jiao Su, Jin Xu, Ying Chen, Yun Xiang,* Ruo Yuan, Yaqin Chai, Sensitive detection of copper(II) by a commercial glucometer using click chemistry, Biosensors & Bioelectronics, 2013, 45,219–222.

14.Qiong Wang, Bingying Jiang, Jin Xu, Jiaqin Xie, Yun Xiang,* Ruo Yuan, Yaqin Chai, Amplified terminal protection assay of small molecule/protein interactions via a highly characteristic solid-state Ag/AgCl process, Biosensors & Bioelectronics, 2013, 43, 19–24.

15.Ling Kong, Jin Xu, Yunying Xu, Yun Xiang,* Ruo Yuan, Yaqin Chai, A universal and label-free aptasensor for fluorescent detection of ATP and thrombin based on SYBR Green I dye, Biosensors & Bioelectronics, 2013, 42, 193–197.

16.Ying Chen, Jin Xu, Jiao Su, Yun Xiang,* Ruo Yuan,* Yaqin Chai, In situ hybridization chain reaction amplification for universal and highly sensitive electrochemiluminescent detection of DNA, Analytical Chemistry, 2012, 84, 7750–7755.

17.Jin Xu, Bingying Jiang, Jiaqing Xie, Yun Xiang,* Ruo Yuan, Yaqin Chai, Sensitive point-of-care monitoring of HIV related DNA sequences with a personal glucometer, Chemical Communications, 2012, 48, 10733–10735.

18.Jiao Su, Jin Xu, Ying Chen, Yun Xiang,* Ruo Yuan, Yaqin Chai, Personal glucose sensor for point-of-care early cancer diagnosis, Chemical Communications, 2012, 48, 6909–6911.

19.Jin Xu, Bingying Jiang, Jiao Su, Yun Xiang,* Ruo Yuan, Yaqin Chai, Background current reduction and biobarcode amplification for label-free, highly sensitive electrochemical detection of pathogenic DNA, Chemical Communications, 2012, 48, 3309–3311.

20.Bingying Jiang, Min Wang, Ying Chen, Jiaqing Xie, Yun Xiang,* Highly sensitive electrochemical detection of cocaine on graphene/AuNP modified electrode via catalytic redox-recycling amplification, Biosensors & Bioelectronics, 2012, 32, 305–308.

21.Haixia Zhang, Bingying Jiang, Yun Xiang,* Yaqin Chai, Ruo Yuan,* Label-free and amplified electrochemical detection of cytokine based onhairpin aptamer and catalytic DNAzyme, Analyst, 2012, 137, 1020–1023.

22.Qiong Wang, Jiao Su, Jin Xu, Yun Xiang,* Ruo Yuan, Yaqin Chai, Dual amplified, sensitive electrochemical detection of pathogenic sequencesbased on biobarcode labels and functional graphene modified electrode, Sensors and Actuators, B 2012, 163, 267–271.

23.Yun Xiang, Mingyi Xie, Ralph Bash, Julian J. L. Chen, Joseph Wang,* Ultrasensitive label-free aptamer-based electronic detection, Angewandte Chemie-International Edition, 2007, 46, 9054–9056.

24.Yun Xiang,* Haixia Zhang, Bingying Jiang, Yaqin Chai, Ruo Yuan,* Quantum dot layer-by-layer assemblies as signal amplification labels for ultrasensitive electronic detection of uropathogens, Analytical Chemistry, 2011, 83, 4302–4306.

25.Ying Chen, Bingying Jiang, Yun Xiang,* Yaqin Chai, Ruo Yuan,* Target recycling amplification for sensitive and label-free impedimetric genosensing based on hairpin DNA and graphene/Au nanocomposites Chemical Communications, 2011, 47, 12798–12800.

26.Jiao Su, Haijie Zhang, Bingying Jiang, Huzhi Zheng, Yaqin Chai, Ruo Yuan, Yun Xiang,* Dual signal amplification for highly sensitive electrochemical detection of uropathogens via enzyme-based catalytic target recycling, Biosensors & Bioelectronics, 2011, 29, 184–188.

27.Yun Xiang,* Xiaoqing Qian, Bingying Jiang, Yaqin Chai, Ruo Yuan,* An aptamer-based signal-on and multiplexed sensing platform for one-spot simultaneous electronic detection of proteins and small molecules, Chemical Communications, 2011, 47, 4733–4735.

28.Yun Xiang,* Xiaoqing Qian, Ying Chen, Yuyong Zhang, Yaqin Chai, Ruo Yuan,* A reagentless and disposable electronic genosensor: from multiplexed analysis to molecular logic gates, Chemical Communications, 2011, 47, 2080–2082.

29.Ying Chen, Bingying Jiang, Yun Xiang,* Yaqin Chai, Ruo Yuan,* Aptamer-based highly sensitive electrochemiluminescent detection of thrombin via nanoparticle layer-by-layer assembled amplification labels, Chemical Communications, 2011, 47, 7758–7760.

30.Haixia Zhang, Bingying Jiang, Yun Xiang,* Jiao Su, Yaqin Chai, Ruo Yuan,* DNAzyme-based highly sensitive electronic detection of lead via quantum dot-assembled amplification labels, Biosensors & Bioelectronics, 2011, 29, 135–138.

31.Yun Xiang,* Xiaoqing Qian, Yuyong Zhang, Ying Chen, Yaqin Chai, Ruo Yuan,* A reagentless, disposable and multiplexed electronic biosensing platform: Application to molecular logic gates, Biosensors & Bioelectronics, 2011, 26, 3077–3080.

32.Haixia Zhang, Bingying Jiang, Yun Xiang,* Yuyong Zhang, Yaqin Chai, Ruo Yuan,* Aptamer/quantum dot-based simultaneous electrochemical detection of multiple small molecules, Analytica Chimica Acta, 2011, 688, 99–103.

33.Yun Xiang,* Yuyong Zhang, Bingying Jiang, Yaqin Chai, Ruo Yuan,* Multi-enzyme layer-by-layer assembly for dual amplified ultrasensitive electronic detection of cancer biomarkers, Sensors and Actuators, B 2011, 15, 317–322.

34.Yuyong Zhang, Yun Xiang,* Yaqin Chai, Ruo Yuan,* Xiaoqing Qian, Haixia Zhang, Gold nanolabels and enzymatic recycling dual amplification-based electrochemical immunosensor for the highly sensitive detection of carcinoembryonic antigen, Sci. China Ser. B 2011, 54, 1770–1776.

35.Yun Xiang,* Yuyong Zhang, Yue Chang, Yaqin Chai, Joseph Wang,* Ruo Yuan,* Reverse-micelle synthesis of electrochemically encoded quantum dot barcodes: Application to electronic coding of a cancer marker, Analytical Chemistry, 2010, 82, 1138–1141.

36.Xiaoqing Qian, Yun Xiang,* Haixia Zhang, Ying Chen, Yaqin Chai, Ruo Yuan,* Aptamer/nanoparticle-based sensitive, multiplexed electronic coding of proteins and small biomolecules through a backfilling strategy, Chemistry-An European Journal, 2010, 16, 14261–14265.

37.Yun Xiang,* Yuyong Zhang, Xiaoqing Qian, Yaqin Chai, Joseph Wang, Ruo Yuan,* Ultrasensitive aptamer-based protein detection via a dual amplified biocatalytic strategy, Biosensors & Bioelectronics, 2010, 25, 2539–2542.

38.Yuyong Zhang, Yun Xiang,* Yaqin Chai, Ruo Yuan,* Aptamer-based competitive electrochemical assay of small biomolecules, Sci. China Ser. B 2011, 54, 822–826.

39.Siriwan Suwansa-ard, Yun Xiang, Ralph Bash, Panote Thavarungkul, Proespichaya Kanatharana, Joseph Wang,* Prussian blue dispersed sphere catalytic labels for amplified electronic detection of DNA, Electroanalysis 2008, 20, 308–312.

40.Apon Numnuam, Karin Y. Chumbimuni-Torres, Yun Xiang, Ralph Bash, Panote Thavarungkul, Proespichaya Kanatharana, Erno1 Pretsch,* Joseph Wang,* Eric Bakker,* Aptamer-based potentiometric measurements of proteins using ion-selective microelectrodes, Analytical Chemistry, 2008, 80, 707–712.

41.Apon Numnuam, Karin Y. Chumbimuni-Torres, Yun Xiang, Ralph Bash, Panote Thavarungkul, Proespichaya Kanatharana, Erno1 Pretsch,* Joseph Wang,* Eric Bakker,* Potentiometric detection of DNA hybridization, Journal of the American Chemical Society, 2008, 130, 410–411.

42.Zong Dai, Abdel-Nasser Kawde, Yun Xiang, Jeffrey T. La Belle, Jared Gerlach, Veer P. Bhavanandan, Lokesh Joshi,* Joseph Wang,* Nanoparticle-based sensing of glycan-lectin interactions, Journal of the American Chemical Society, 2006, 128, 10018–10019.

43.Jacob A. Hansen, Joseph Wang,* Abdel-Nasser Kawde, Yun Xiang, Kurt V. Gothelf, Greg Collins, Quantum-dot/aptamer-based ultrasensitive multi-analyte electrochemical biosensor, Journal of the American Chemical Society, 2006, 128, 2228–2229.

44.Karin Y. Chumbimuni-Torres, Zong Dai, Nastassia Rubinova, Yun Xiang, Erno Pretsch,* Joseph Wang,* Eric Bakker*, Potentiometric biosensing of proteins with ultrasensitive ion-selective microelectrodes and nanoparticle labels, Journal of the American Chemical Society, 2006, 128, 13676–13677.

45.Anchana Preechaworapun, Zong Dai, Yun Xiang, Orawon Chailapakulb,* Joseph Wang,* Investigation of the enzyme hydrolysis products of the substrates of alkaline phosphatase in electrochemical immunosensing, Talanta, 2008, 76, 424–431.