中国药科大学

张建军硕士生导师简介

教育、工作经历：

1996-2000年硕士中国药科大学药物制剂
2002-2005年博士中国药科大学药物制剂
2000.11-2002.3国家药品审评中心
2005,11-2006,8香港浸会大学访问学者
2010.7-2011.12江苏四环生物股份有限公司技术总监（企业柔性人才挂职）
2013.7-2014.6美国明尼苏达大学访问学者
2002.4-至今中国药科大学药学院药剂教研室，中国药科大学-震元制药制剂合作开发实验室负责人

主要研究方向：新制剂与新技术研究

具体研究兴趣为：

1）药物晶体工程
2）共晶及共无定型理论与技术
3）新液晶材料及其给药系统
4）缓控释制剂技术
5）纳米制剂技术

基本情况：

副教授，硕士生导师，国家食品药品监督管理局药品审评专家。2010年获中国药学会-石药青年药剂学奖，2013年获药明康德生命化学奖，2014年获江苏省青蓝工程中青年学术带头人。

主持了逾40余项校企合作课题的研究与产业化，研究剂型及技术全面，在应用技术领域及制剂生产第一线，在推动技术创新和科技成果转化等方面有非常丰富的研发经验和产业化经验。参与国家重大新药创制技术平台和多项重大新药创制项目。目前已申请专利40余项，已授权16项，转让5项。

注重药物制剂理论基础尤其是药物晶体学的深入研究，重视新技术、新剂型的应用基础，发表SCI论文26篇（第一作者或通讯作者），国内EI及核心期刊论文几十篇，《中药制剂新剂型与新技术》的副主编，并参与编写了《药剂学》、《药剂学实验》等多部药剂学教材。

代表性SCI文章：

Zhang J, Gao Y, Qian S, Liu X, Zu H. Physicochemical and pharmacokinetic characterization of a spray-dried malotilate emulsion. Int J Pharm, 2011, 414(1-2):186-192.

Liu Y, Zhang J (contribution equally), Gao Y, Zhu J. Preparation and evaluation of glyceryl monooleate-coated hollow-bioadhesive microspheres for gastroretentive drug delivery. Int J Pharm, 2011, 413(1-2):103-109.

Gao Y, Qian S, Zhang J. Physicochemical and pharmacokinetic characterization of a spray-dried cefpodoxime proxetil nanosuspension. Chem Pharm Bull 2010, 58(7): 912-917.

Zhang J, Gao Y, Su F, Gong Z, Zhang Y. Interaction characteristics with bovine serum albumin and retarded nitric oxide release of ZCVI(4)-2, a new nitric oxide-releasing derivative of oleanolic acid. Chem Pharm Bull. 2011, 59(6): 734-741.

Gao Y, Zu H, Zhang J*. Enhanced dissolution and stability of adefovir dipivoxil by cocrystal formation. J Pharm Pharmacol, 2011, 63(4): 483–490.

Zhang J, Zu H, Gao Y. Formation thermodynamics of adefovir dipivoxil-saccharin co-crystals. Acta Phys Chim Sin, 2011, 27(3): 547-552.

Gao Y, Zu H, Zhang J*. Pharmaceutical cocrystals. Prog Chem, 2010,22(5): 829-836.

Gao Y, Sun WJ, Zhang J*. Optimization of preparation and property studies on glycosylated albumin as drug carrier for nanoparticles. Pharmazie, 2011, 66(7): 484-490.

Gao Y, Sun WJ, Zhang J*. Albumin as drug carriers. Prog Chem, 2011, 23(8): 168-176.

Zhang J, Li C, Gao Y. Effect of poloxamer F 127 and paeonol on GMO-based liquid crystal transformation. Acta Chim Sin, 2011, 69(13): 1503-1508.

Zhang J, Lv H, Jiang K, Gao Y*. Enhanced bioavailability after oral and pulmonary administration of baicalein nanocrystal. Int J Pharm. 2011, 420(1):180-188.

Zhang J, Zheng Z, Gao Y*, Zhang Y. Spray-dried oil-in-water emulsion to improve the intestinal absorption and oral bioavailability of ZLR-8, a nitric oxide-releasing derivative of diclofenac. J Pharm Pharmacol, 2011, 63(12):1531-1538.

Gao Y, Li L,Zhang J*, Su F, Gong Z, Lai Y, Zhang Y. Physicochemical characterization and an injection formulation study of water insoluble ZCVI4-2，a novel NO-donor anti-cancer compound. Arch Pharm Res, 2012, 35(7): 1177-1186.

Zhang J, Liu D, Huang Y, Gao Y, Qian S. Biopharmaceutics classification and intestinal absorption study of apigenin. Int J Pharm, 2012, 436(1-2): 311-317.

Gao Y, Gao J, Liu Z, Kan H, Zu H, Sun W, Zhang J*, Qian S. Coformer selection based on degradation pathway of drugs: a case study of adefovir dipivoxil-saccharin and adefovir dipivoxil-nicotinamide cocrystals. Int J Pharm, 2012, 438(1-2): 327-335

Zhang J, Tan X, Gao J, Fan W, Gao Y, Qian S. Polymorphism of lornoxicam. J Pharm Pharmacol, 2013, 65(1): 44-52.

Zhang J, Huang Y, Liu D, Gao Y, Qian S. Preparation of apigenin nanocrystals using supercritical antisolvent process for dissolution and bioavailability enhancement. Eur J Pharm Sci, 2013, 48(4–5): 740–747.

Y Gao, J Liao, X Qi, J Zhang*. Coamorphous repaglinide–saccharin with enhanced dissolution. Int J Pharm, 2013, 450(1-2): 290-295.

Ma K, Zhang Y, Kan H, Cheng L, Luo L, Su Q, Gao J, Gao Y, Zhang J*. Thermodynamic and kinetic investigation on the crucial factors affecting adefovir dipivoxil-saccharin cocrystallization. Pharm Res, 2014, 31(7): 1766-1778.

Zhang J, Fu M, Zhang M, Xu L, Gao Y. Synthesis of oxidized glycerol monooleate-chitosan polymer and its hydrogel formation for sustained release of trimetazidine hydrochloride. Int J Pharm, 2014, 465(1-2):32-41.

Guo H, Miao N, Li T, Hao J, Gao Y, Zhang J*. Pharmaceutical coamorphous-a newly defined single-phase amorphous binary system. Prog Chem, 2014, 26(2-3): 478-486.

Huang Y, Zhang B, Gao Y, Zhang J*, Shi L. Baicalein-nicotinamide cocrystal with enhanced solubility, dissolution and oral bioavailability. J Pharm Sci, 2014, 103(8):2330-2337.

Wei Y, Li L, Xi Y, Qian S, Gao Y, Zhang J*. Sustained release and enhanced bioavailability of injectable scutellarin-loaded bovine serum albumin nanoparticles. Int J Pharm, 2014. Accepted

*: corresponding author

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